• Molecular Dynamics Simulations of Periplasmic Proteins Interacting with the Peptidoglycan Layer of Escherichia coli
    Author:
    Pranav Lalgudi (1) and Adrian H. Elcock (2)
    Focus:
    , ,

    06 April 2016 9:39 PM |

    Molecular dynamics (MD) simulations are a great tool to model and study complex biological systems. In this paper, the authors use MD simulations to construct and simulate a model of the periplasmic space, the peptidoglycan layer and its associated proteins, in an Escherichia coli cell.

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  • The Protective Effects of Panax notoginseng Saponin on the Blood-Brain Barrier via the Nrf2/ARE Pathway in bEnd3 Cells
    Author:
    Jinting Yang (1) and Ningna Zhou (2)
    Focus:
    , ,

    06 April 2016 12:32 AM |

    Disruption of the blood-brain barrier (BBB) is related to many neurological disorders, and can be caused by oxidative stress to cerebral microvascular endothelial cells (CMECs) composing the BBB. The authors of the paper investigated the protective effects of the total saponins in the leaves of Panax notoginseng (LPNS) on oxidative-stress-induced damage in a mouse cerebral microvascular endothelial cell line.

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