Cancer is often caused by improper function of a few proteins, and sometimes it takes only a few proteins to malfunction to cause drastic changes in cells. Here the authors look at the genes that were mutated in patients with a type of pancreatic cancer to identify proteins that are important in causing cancer. They also determined which proteins currently lack effective treatment, and suggest that certain proteins (named KRAS, CDKN2A, and RBBP8) are the most important candidates for developing drugs to treat pancreatic cancer.
In this study, the authors looked at a proto-oncogene, KRAS, and searched for molecules that are predicted to be able to bind to the inactive form of KRAS. They found that a modified version of Irbesartan, a derivative of benzimidazole, showed the best binding to inactive KRAS.
Researchers query whether reading comprehension is the same, worse, or better when using e-books as compared with standard paper texts. This study evaluated this question in the elementary school population. Our hypothesis was that information would be retained equally whether read from paper or from an electronic device. Each participant read four stories, alternating between electronic and paper media types. After each reading, the participants completed a five-question test covering the information read. The study participants correctly answered 167 out of 200 comprehension questions when reading from an electronic device. These same participants correctly answered 145 out of 200 comprehension questions when reading from paper. At a significance level of p < 0.05, the results showed that there was a statistically significant difference in reading comprehension between the two media, demonstrating better comprehension when using electronic media. The unexpected results of this study demonstrate a shift in children’s performance and desirability of using electronic media as a reading source.
Semantic segmentation - labelling each pixel in an image to a specific class- models require large amounts of manually labeled and collected data to train.
The authors investigate the ability of machine learning models to developing new drug-like molecules by learning desired chemical properties versus simply generating molecules that similar to those in the training set.
Due to the susceptibility of adolescent age groups to opioid misuse, here the authors sought to determine if there was a difference in the perception and knowledge between 9th and 12th graders regarding the opioid crisis. An educational intervention trial was done with the 9th graders and surveys were used to identify its effects. Although the authors acknowledge a small sample size, their results suggest that their are gaps within the knowledge of adolescents in regards to opioid misuse and its long-term effects that could be addressed with further education.
Concerns regarding the rapid spread of Sars-CoV2 in early 2020 led company and local governmental officials in many states to ask people to work from home and avoid leaving their homes; measures commonly referred to as shutdowns. Here, the authors investigate how shutdowns affected carbon monoxide (CO) levels in 15 US states using publicly available data. Their results suggest that CO levels decreased as a result of these measures over the course of 2020, a trend which started to reverse after shutdowns ended.
In this study, the authors investigate the demographic indicators for voter shift between the 2016 and 2020 presidential elections based on demographic data put through a K-nearest neighbors classification algorithm and Principal Component Analysis.
In this article, Harvell and Nicholson hypothesized that increased ocean acidity would decrease the photosynthetic ability of Chaetoceros gracilis, a diatom prolific in Monterey Bay, because of the usually corrosive effects of carbonic acid on both seashells and cells’ internal structures. They altered pH of algae environments and measured the photosynthetic ability of diatoms over four days by spectrophotometer. Overall, their findings indicate that C. gracilis may become more abundant in Monterey Bay as the pH of the ocean continues to drop, potentially contributing to harmful algal blooms.
Oil spills are one of the most devastating events for marine life. Finding ways to clean up oil spills without the need for harsh chemicals could help decrease the negative impact of such spills. Here the authors demonstrate that using a combination of several biodegradable substances can effectively adsorb oil in seawater in a laboratory setting. They suggest further exploring the potential of such a combination as a possible alternative to commonly-used non-biodegradable substances in oil spill management.
