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Combating Insulin Resistance Using Medicinal Plants as a Supplementary Therapy to Metformin in 3T3-L1 Adipocytes: Improving Early Intervention-Based Diabetes Treatment

Jayram et al. | Apr 08, 2019

Combating Insulin Resistance Using Medicinal Plants as a Supplementary Therapy to Metformin in 3T3-L1 Adipocytes: Improving Early Intervention-Based Diabetes Treatment

A primary cause of diabetes is insulin resistance, which is caused by disruption of insulin signal transduction. The objective of this study was to maximize insulin sensitivity by creating a more effective, early intervention-based treatment to avert severe T2D. This treatment combined metformin, “the insulin sensitizer”, and medicinal plants, curcumin, fenugreek, and nettle.

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Don’t Waste the Medical Waste: Reducing Improperly Classified Hazardous Waste in a Medical Facility

Hemani et al. | Jun 20, 2018

Don’t Waste the Medical Waste: Reducing Improperly Classified Hazardous Waste in a Medical Facility

Hemani et al. tackled the problem of rampant hospital waste by implementing staff training to help inform hospital workers about proper waste disposal. The authors observed a significant increase in proper waste disposal after the training, showing that simple strategies, such as in-person classroom training and posters, can have a profound effect on limiting improper waste handling.

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Leaky expression of PRMT1 in Escherichia coli and redox regulation of its histone methyltransferase activity

Kim et al. | Oct 07, 2026

Leaky expression of PRMT1 in <i>Escherichia coli</i> and redox regulation of its histone methyltransferase activity

This study characterizes recombinant human Protein arginine methyltransferase 1 (PRMT1) expressed in Escherichia. coli and reveals that the enzyme exhibits leaky expression even without isopropyl β-D-1-thiogalactopyranoside (IPTG) induction. Through in vitro histone methyltransferase assays, we demonstrate that PRMT1 activity toward histone H4R3 is enhanced by dithiothreitol (DTT) in a dose-dependent manner but remains unresponsive to β-mercaptoethanol. These findings highlight the critical role of redox conditions in regulating PRMT1 catalytic function and provide a practical framework for future biochemical and kinetic studies.

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Global trends in total cholesterol by gender (1980-2018)

Qi et al. | Aug 24, 2026

Global trends in total cholesterol by gender (1980-2018)

This study explores global trends in average total cholesterol levels among adults from 1980 to 2018, finding a significant decline in both men and women, with a sharper decrease among men. While these improvements likely reflect advances in public health and medical treatment, the persistent gender gap highlights the need for more targeted approaches to cardiovascular disease prevention.

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