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Talinum paniculatum root exhibits synergistic antimicrobial activity with Tetracycline, Erythromycin, and Streptomycin against S. aureus but has no observed effect on antibiotic efficacy against E. coli

Patel et al. | Jan 09, 2018

Talinum paniculatum root exhibits synergistic antimicrobial activity with Tetracycline, Erythromycin, and Streptomycin against S. aureus but has no observed effect on antibiotic efficacy against E. coli

Patel et al. explore whether T. paniculatum plant extract can work with modern antibiotics to increase antibiotic efficacy against common disease-causing bacteria. The plant extract in conjunction with the antibiotic shows promise in battling S. aureus. The authors present a cost-effective method to increase antibiotic efficacy in a time where antibiotic resistant bacteria is becoming a growing problem.

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Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Jang et al. | Aug 19, 2016

Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.

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Friend or Foe: Investigating the Relationship between a Corn Crop and a Native Ragweed Population

Wainwright et al. | May 07, 2014

Friend or Foe: Investigating the Relationship between a Corn Crop and a Native Ragweed Population

Farmers will need to increase crop yields to feed the world's growing population efficiently. The authors here investigate the effects of growing corn in the presence or absence of ragweed, an invasive weed found in many fields and gardens. Surprisingly, the authors found that corn grown in the presence of weeds grew taller and were more productive than corn that had weeds removed. This may help gardeners rethink the necessity of weeding, and may point a way to improve farm yields in the future.

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Investigating auxin import and export proteins in Chlorella vulgaris

Wang et al. | Apr 19, 2025

Investigating auxin import and export proteins in <i>Chlorella vulgaris</i>

This study explores auxin signaling in Chlorella vulgaris, a green alga with potential for sustainable biofuel and food production. Evidence from protoplast swelling experiments suggests that C. vulgaris secretes auxin and possesses auxin import proteins, highlighting previously uncharacterized signaling pathways. These findings could support more efficient cultivation and resource extraction strategies.

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Unveiling the wound healing potential of umbilical cord derived conditioned medium: an in vitro study

Vasal et al. | Jun 17, 2024

Unveiling the wound healing potential of umbilical cord derived conditioned medium: an <em>in vitro</em> study

Chronic wounds pose a serious threat to an individual’s health and quality of life. However, due to the severity and morbidity of such wounds, many pre-existing treatments are inefficient or costly. While the use of skin grafts and other such biological constructs in chronic wound healing has already been characterized, the use of umbilical cord tissue has only recently garnered interest, despite the cytokine-rich composition of Wharton’s jelly (cord component). Our current study aimed to characterize the use of an umbilical cord derived conditioned medium (UC-CM) to treat chronic wounds.

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The effect of molecular weights of chitosan on the synthesis and antifungal effect of copper chitosan

Byakod et al. | Apr 07, 2024

The effect of molecular weights of chitosan on the synthesis and antifungal effect of copper chitosan

Pathogenic fungi such as Alternaria alternata (A. alternata) can decimate crop yields and severely limit food supplies when left untreated. Copper chitosan (CuCts) is a promising alternative fungicide for developing agricultural areas due to being inexpensive and nontoxic. We hypothesized that LMWc CuCts would exhibit greater fungal inhibition due to the beneficial properties of LMWc.

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Effect of Gram-positive bacteria on antibiotic resistance in Gram-negative bacteria

Willem et al. | Mar 12, 2024

Effect of Gram-positive bacteria on antibiotic resistance in Gram-negative bacteria

Antibiotics are one of the most common treatments for bacterial infections, but the emergence of antibiotic resistance is a major threat to the control of infectious diseases. Many factors contribute to the development of antibiotic resistance. One is bacterial conjugation from Gram-positive to Gram-negative bacteria where there is a transfer of resistance genes from Gram-positive to Gram-negative bacteria that could increase antibiotic resistance in the latter. In light of these observations, we decided to test whether Gram-negative bacteria that came into contact with Gram-positive bacteria had a higher resistance to the antimicrobial properties of spices than Gram-negative bacteria that did not come into contact with Gram-positive bacteria.

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