T. pyriformis can use phagocytosis to create vacuoles of carmine red, a dye which is made using crushed insects and is full of nutrients. Establishing a relationship between vacuole formation and duration of exposure to food can demonstrate how phagocytosis occurs in T. pyriformis. We hypothesized that if T. pyriformis was incubated in a carmine red solution, then more vacuoles would form over time in each cell.
In this study, the authors test whether providing a larger dataset of glass transition temperatures (Tg) to train the machine-learning platform Polymer Genome would improve its accuracy. Polymer Genome is a machine learning based data-driven informatics platform for polymer property prediction and Tg is one property needed to design new polymers in silico. They found that training the model with their larger, curated dataset improved the algorithm's Tg, providing valuable improvements to this useful platform.
In this study, the authors look into some of the implications of rising carbon dioxide levels by studying the effects of acidic pH on the ability of T. pyriformis to feed by quantifying phagosome formation and motility.
Patel et al. explore whether T. paniculatum plant extract can work with modern antibiotics to increase antibiotic efficacy against common disease-causing bacteria. The plant extract in conjunction with the antibiotic shows promise in battling S. aureus. The authors present a cost-effective method to increase antibiotic efficacy in a time where antibiotic resistant bacteria is becoming a growing problem.
The surface of the unicellular eukaryote, Tetrahymena pyriformis, is covered with thousands of hair-like cilia. These cilia are very similar to cilia of the human olfactory and respiratory tracts making them model organisms for studying cilia function and pathology. The authors of this study investigated the effect of voltage on T. pyriformis galvanotaxis, the movement towards an electrical stimulus. They observed galvanotaxis towards the cathode at voltages over 4V which plateau, indicating opening of voltage gated-ion channels to trigger movement.
The authors compared the short-term effects of processed versus unprocessed food on spatial learning and survival in zebrafish, given the large public concern regarding processed foods. By randomly assigning zebrafish to a diet of brine shrimp flakes (processed) or live brine shrimp (unprocessed), the authors show while there is no immediate effect on a fish's decision process between the two diets, there are significant correlations between improved learning and stress response with the unprocessed diet.
In this study, Imani et al. investigate whether a new proprietary herbal formulation, HF1, can inhibit expression of immune suppressor protein PD-L1. PD-L1 is a transmembrane protein that can be expressed by cancer cells to assist in their ability to avoid attacks from the immune system. Work from this study demonstrates that HF1 treatment can reduce expression of PD-L1 in cultured cancer cells, implicating HF1 as a potential new cancer therapy.
In this study, the authors identify new potential targets to treat advanced diffuse large B-cell lymphoma after treatment relapse and loss of CD19 expression.
In this study, a deep learning model is used to classify post-traumatic stress disorder patients through novel markers to assist in finding candidate biomarkers for the disorder.
The lexical decision task is designed to test aspects of vocabulary retrieval from short-term and long-term memory by prompting the subject to differentiate between words and non-words. From this task, researchers can determine the effects of certain stimuli on linguistic processing. Numerous studies have investigated the effects of music on various cognitive capacities, like memory and vocabulary. In the current study, we hypothesized that participants would show greater accuracy rates on the lexical decision task when exposed to a selected piece of classical music while completing the task, as compared to completing the task in silence. We tested this hypothesis on a group of 25 participants who completed the lexical decision task once in silence and once while listening to Beethoven's “Moonlight Sonata, 1st Movement”. The results suggest a positive association between the effects of classical background music and improved accuracy. Our results indicate that listening to certain types of music may enhance linguistic processes such as reading and writing. Further research with a larger group of participants is necessary to better understand the association between music and linguistic processing abilities.