The current five-year survival rate of metastasized prostate cancer is only 30% and occurs in every one in nine men. Researchers have shown that people with a type of dwarfism called Laron’s Syndrome are immune to cancer due to their low levels of insulin-like growth factor-1 (IGF-1). For this reason, experimentally modifying the level of IGF-1 could provide better insight into whether lowering the levels of IGF-1 in prostate cancer cell lines (e.g. PC-3) could be an effective treatment to reduce their rates of proliferation and migration and increase apoptosis. We selected three compounds, which researchers have shown decrease IGF-1 levels, to test and combine to determine which is the most promising.

Control of voluntary and involuntary movements is one of the most important aspects of human neurological function, but the mechanisms of motor control are not completely understood. In this study, the authors use transcranial magnetic stimulation (TMS) to stimulate a portion of the motor cortex while subjects performed either discrete (e.g. throwing) or rhythmic (e.g. walking) movements. By recording electrical activity in the muscles during this process, the authors showed that motor evoked potentials (MEPs) measured in the muscles during TMS stimulation are larger in amplitude for discrete movements than for rhythmic movements. Interestingly, they also found that MEPs during transitions between rhythmic and discrete movements were nearly identical and larger in amplitude than those recorded during either rhythmic or discrete movements. This research provides important insights into the mechanisms of neurological control of movement and will serve as the foundation for future studies to learn more about temporal variability in neural activity during different movement types.

The authors looked at the ability to grow S. platensis on a larger scale with reduced cost given that it is currently quite expensive to grow, but poses as an important food source in the future.

In this study, the authors investigate the effects of acetone on the color of copper chloride (CuCl₂) solution, which has important implications for detecting copper in the environment.

Here, recognizing the recognizing the growing threat of non-biodegradable plastic waste, the authors investigated the ability to use a modified enzyme identified in bacteria to decompose polyethylene terephthalate (PET). They used simulations to screen and identify an optimized enzyme based on machine learning models. Ultimately, they identified a potential mutant PETases capable of decomposing PET with improved thermal stability.

Here, recognizing the important role of bacterial biofilms in many life-threatening chronic infections, the authors investigated the effectiveness of a combination treatment on biofilms composed of up to three different common species within the lungs of cystic fibrosis patients with computational analysis. They found that a triple cocktail therapy targeting three different signaling pathways has significant potential as both a treatment and prophylaxis.

Many diabetics agree that the current glucometer methods are invasive, inefficient, and unsustainable for measuring blood glucose. These authors investigate the possibility of using a non-invasive glucometer patch that predicts blood glucose from patient sweat, with high accuracy.

In this study, the authors test the effect that the tilt angle of a solar panel has on the amount of energy it generates. This investigation highlights a simple way that people can harvest renewable energy more efficiently and effectively.

Wearing face masks has become a common occurrence in everyday life and during athletics due to the spread of diseases. This study tested if masks would affect blood percent saturation of hemoglobin (SpO₂) during treadmill exercise. The data analysis showed that mask type, time, and the interaction of mask type and time were significant results, regardless of physical ability. These results may assist athletes in understanding the differences between training and competing with and without a mask.

Here, seeking a way to convert the vast quantity of seawater to drinking water, the authors investigated the purification of seawater to drinking water through electrodialysis. Using total dissolved solids (TDS) as their measure, they found that electrodialysis was able to produce deionized water with TDS values under the acceptable range for consumable water.