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Optical reporters like tetrazolium dyes, exemplified by 5-diphenyl tetrazolium bromide (MTT), are effective tools for quantifying cellular responses under experimental conditions. These dyes assess cell viability by producing brightly-colored formazan dyes when reduced inside active cells. However, certain small molecules, including reducing agents like ascorbic acid, cysteine, and glutathione (GSH), can interfere with MTT assays, potentially compromising accuracy.

Here the authors performed a comparative analysis to investigate the viability of using PLAY® instead of fetal bovine serum (FBS) as a growth medium to culture cells with an enzyme-linked immunosorbent assay.

In this article, the authors identify the characteristics that make a book a best-seller. Knowing what, besides content, predicts the success of a book can help publishers maximize the success of their print products.

FBS is an important component in in vitro cell culture work, helping to provide needed nutrients to cells to grow. The authors look at the ability of an alternative to FBS to support cell growth in culture.

Identifying treatments that can stimulate hair growth use could help those struggling with undesirable hair loss. Here, the authors show that Fibroblast Growth Factors can stimulate the division of cells isolated from the mouse hair follicle. Their results suggest that this family of growth factors might be helpful in stimulating hair growth in living animals as well.

Acquired immunodeficiency syndrome (AIDS) is a life-threatening condition caused by the human immunodeficiency virus (HIV). In this work, Takemaru et al explored the role of Coiled-Coil Domain-Containing 11 (CCDC11) in HIV-1 budding. Their results suggest that CCDC11 is critical for efficient HIV-1 budding, potentially indicating CCDC11 a viable target for antiviral therapeutics without major side effects.

Aquaponics (the combination of aquatic plant farming with fish production) is an innovative farming practice, but the fish that are typically used, like tilapia, are expensive and space-consuming to cultivate. Medina and Alvarez explore other options test if mosquitofish are a viable option in the aquaponic cultivation of herbs and microgreens.

The authors looked at beach nourishment (a way to combat erosion on coasts) and resulting grain size distribution. Their work is important to understand the dynamics of erosion and it's relation to wave action and the implications this has for efforts to mitigate coastal erosion.

Here the authors examined the relationship between education levels and the gender wage gap (GWG) in the US and Puerto Rico from 2010 to 2022, hypothesizing that higher education would correlate with a lower GWG. Their analysis of income data revealed an inverse correlation, where higher education levels were associated with reduced gender wage disparities, suggesting that policies aimed at closing the gender gap in higher education could promote socioeconomic equality.

The authors analyze political endorsement patterns and impacts from the 2018 and 2020 midterm elections and find that such endorsements may be predictable based on the ideological and demographic factors of the endorser.