Browse Articles

In this study, the authors observe if the symptoms of Rett Syndrome, a neurodegenerative disease in humans, are reflected in Drosophila melanogaster. This was achieved by differentiating the behavior and physical aspects of wild-type flies from flies expressing the full-length MeCP2 gene and the mutated MeCP2 gene (R106W). After conducting these experiments, some of the Rett Syndrome symptoms were recapitulated in Drosophila, and a subset of those were partially ameliorated by the introduction of pifithrin-alpha.

Cancer is often caused by improper function of a few proteins, and sometimes it takes only a few proteins to malfunction to cause drastic changes in cells. Here the authors look at the genes that were mutated in patients with a type of pancreatic cancer to identify proteins that are important in causing cancer. They also determined which proteins currently lack effective treatment, and suggest that certain proteins (named KRAS, CDKN2A, and RBBP8) are the most important candidates for developing drugs to treat pancreatic cancer.

In this study, we investigated how the complexity of a query can influence tool-use hallucinations in large language models that were tasked with setting an appointment. Using explainable AI (XAI) as a tool to test the hypothesis, we analyzed trends in hallucination rates by the type of query and saw results that when complexity and ambiguity of the query increased (such as asking for multiple days or unclear time ranges), the model was more likely to make errors due to misunderstanding time-related data from tool outputs. This shows that making large language models (LLMs) understand what seems logical to a human is still difficult, especially in complex tasks, and that knowing what causes these errors can help build more trustworthy AI systems.

The authors examine the factors that impact a ballet master's career.

This study compares traditional and discovery-based instructional methods in online middle school mathematics education. Findings show that discovery-based learning significantly improves students’ academic performance and attitudes, highlighting the value of inquiry-driven instruction for enhancing both understanding and motivation.

This manuscript tackles a major social issue in the health news sector, with social media being one of the primary sources of information and a prime spot to propagate fake news. The author proposes X-HND , which is a unique architecture that combines emotional and contextual analysis in a Graph Neural Network to accurately detect fake news. This was a multi-step process which involved the creation of a custom health news dataset (HNDataset), and an emotional variant that uses RoBERTa to extract emotion. These dataset were then used to prove the hypothesis that accuracy increases when the custom dataset is used to train the model and that with the integration of emotion capture, the detection accuracy increases further.

Elevated acetylcholinesterase (AChE) activity contributes to cognitive decline and neurodegenerative diseases such as Alzheimer’s, motivating the search for more effective inhibitors with better bioavailability. This study used computational methods to design novel, non-toxic AChE inhibitors.

The authors employ computational protein design to identify a mini-protein with the potential to enhance binding of the tight junction protein, claudin-5, at the blood-blood barrier with therapeutic potential for neurodegenerative diseases.

This study examined the impact of erosion on the performance of a triangular aerofoil at a low Reynolds number (Re = 10,000), relevant for harsh conditions like those on Mars.

Here, recognizing that brain aneurysms pose a severe threat, often misdiagnosed and leading to high mortality, particularly in younger individuals, the authors explored a novel computer-aided engineering approach. They used magnetic resonance angiography images and computational fluid dynamics, to improve aneurysm detection and risk assessment, aiming for more personalized treatment.