Browse Articles

Human immunodeficiency virus (HIV), which affects tens of millions of individuals worldwide, can lead to acquired immunodeficiency syndrome (AIDS). While there is currently no cure for HIV, the development of small molecule antiretroviral agents has greatly improved the prognosis of infected individuals, especially in developed countries. Here, the authors employ homology modeling and molecular docking towards the identification of novel rilpivirine analogs that retain high binding affinity to clinically relevant rilpivirine-resistant mutations of the HIV reverse transcriptase enzyme.

Social psychologist Solomon Asch designed conformity tests to study how peer pressure from a group can influence an individual's own perception and behavior. In this study, students evaluate conformity behavior in a teenage group.

The authors explore hearing students' misconceptions about the Deaf and Hard of Hearing (HoH) community. Results indicate that some misconceptions are more common than others, and that personal experience with individuals in the Deaf and HoH community reduces the frequency of such misconceptions.

Galaxy clusters offer several advantages for measuring H₀ compared to traditional methods, such as Cepheid variables or Type Ia supernovae. Unlike individual stars or supernovae, clusters are less affected by local variations in stellar population or interstellar medium properties, providing a more stable and consistent measure over large cosmological distances. This work proposes using galaxy clusters as an alternative method for determining the H₀. It provides an independent perspective on the H₀ debate and contribute to ongoing efforts to reconcile the differing values obtained from the other two measurements.

This study, uses SimulATe to model changes in microbial diversity and community structure upon administering a cocktail of antibiotics versus a single antibiotic. The authors hypothesized that antibiotic cocktails, particularly those combining broad-spectrum drugs like tetracyclines and trimethoprims, would cause a more significant reduction in gut microbial diversity compared to single-drug treatments. The findings confirmed a greater loss of microbial diversity with combinatorial treatments compared to single-drug treatments. While individual antibiotics dynamically reshaped the surviving species of the microbiome, antibiotic cocktails frequently cleared all species of the gut microbiome.

This manuscript describes a new method of on-the-go passwords using typing characteristics. The authors developed a keyboard and keystroke recording setup and tested it with 30 participants. The results indicated the five chosen parameters are distinct across participants yet consistent across time for each participant, making it a plausible candidate for a behavior-based password system.

This study shows the efficacy of leveraging transfer learning, specifically from residual networks, to detect CVDs and possible signs of CVDs. The findings indicate that leveraging transfer learning from residual networks alongside medical professionals is a highly promising approach for CVD detection and diagnosis, warranting further investigation.

Here the authors investigated a combination therapy to target the Kirsten rat sarcoma viral oncogene homolog mutation in lung cancer, by analyzing publicly available data. Their findings indicate that the combination therapy of CA170 and Kvax enhances helper T cell function and improves cytotoxic T lymphocyte infiltration, while Kvax alone drives plasma and memory B cell proliferation.

The authors looked at how nanosilver particles may negatively impact the pond water environment. They used D. magna as an indicator species to look at the impact of different concentrations of nanosilver particles.

The authors looked at the correlation between being able to speak more than one language (multilingualism) and visual imagery. They found multilingual individuals had higher visual imagery as measured by the VVIQ.