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Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.

Chemicals used in fertilizers and pesticides often end up in nearby bodies of water due to runoff and may have negative impacts on these important ecosystems. In this study, the authors use water containing different nitrogen levels to investigate the effect on the growth of the English daisy.

This study compares the voltage output of two potential alternative energy sources: water drops hitting a piezoelectric surface and water flowing through a hydroelectric turbine. The findings of this study suggest that harnessing kinetic energy from falling raindrops may be a viable alternative energy source.

Insulin infusion patches are a common way for diabetics to receive medication. The durability of two different patch adhesives was compared on artificial skin with and without artificial sweat.

Biomimicry is the practice of applying models and systems found in nature to improve the efficiency and usefulness of human technologies. In this study, the authors designed helicopter blades with tubercle structures similar to those found on the tails of humpback whales. The authors found that certain arrangements of these tubercle structures improved the windspeed and efficiency of a model helicopter.

The authors looked at how vocabulary is impacted in Alzheimer's disease and whether it could be used a predictor of disease onset.

This article describes the classification of medical text data using vector databases and text embedding. Various large language models were used to generate this medical data for the classification task.

Patients with cleft palate frequently struggle with speech issues such as nasal or congested speech. Lin and Parkinson conduct a meta-analysis to determine how two common types of cleft palate repair surgery compare in terms of their effects on patient's speech.

The authors use molecular modeling to test analogs of the stearoyl-coenzyme A desaturase 1 (SCD1) inhibitor MF-438 with implications for future development of Parkinson's disease therapeutics.

The authors looked at the ability to grow S. platensis on a larger scale with reduced cost given that it is currently quite expensive to grow, but poses as an important food source in the future.