This study analyzes genetic alterations and expression patterns of protein kinases involved in phagocytosis across multiple cancers using TCGA data.
Read More...Protein kinases in phagocytosis (phagocytotic kinome): A promising biomarker set in cancer therapeutics
This study analyzes genetic alterations and expression patterns of protein kinases involved in phagocytosis across multiple cancers using TCGA data.
Read More...Applying centrality analysis on a protein interaction network to predict colorectal cancer driver genes
In this article the authors created an interaction map of proteins involved in colorectal cancer to look for driver vs. non-driver genes. That is they wanted to see if they could determine what genes are more likely to drive the development and progression in colorectal cancer and which are present in altered states but not necessarily driving disease progression.
Read More...Legacy mercury, reservoir dynamics, and dredging effects on methylmercury in San Francisco Bay
This study analyzes over two decades of monitoring data (1999-2022) to investigate how legacy mining, reservoir water releases, and dredging activities influence toxic methylmercury (MeHg) levels in San Francisco Bay. The findings reveal a significant delayed correlation between river flow and San Francisco Bay MeHg, and counter to the authors' hypothesis, a strong association between increased MeHg concentrations in the bay and both total annual dredging volume and beneficial sediment reuse / upland sediment disposal.
Read More...Surface cleanliness of hydrothermally grown zinc oxide microparticles compared to commercial nanoparticles
The authors test the usefulness of zinc oxide microparticles relative to zinc oxide nanoparticles as antibacterial agents.
Read More...Upregulation of the AP-1 complex as a potential biomarker for Alzheimer’s disease (AD)
Investigating the effects of glucose reintroduction on acutely starved HeLa cells
Cancer cells rely heavily on glycolysis, but how they respond when glucose is reintroduced after acute starvation is not well understood. Using fluorescence lifetime imaging microscopy, students tracked metabolic changes in HeLa cells and found a rapid shift toward glycolysis within 20 minutes of glucose reintroduction, followed by heterogeneous recovery toward oxidative phosphorylation. These results highlight metabolic flexibility and variability in cancer cells, offering insights relevant to treatment resistance and therapeutic design.
Read More...VISTA inhibitor CA170 combined with KRAS vaccine enhances immune response in lung cancer
Here the authors investigated a combination therapy to target the Kirsten rat sarcoma viral oncogene homolog mutation in lung cancer, by analyzing publicly available data. Their findings indicate that the combination therapy of CA170 and Kvax enhances helper T cell function and improves cytotoxic T lymphocyte infiltration, while Kvax alone drives plasma and memory B cell proliferation.
Read More...Locating carcinogenic per- and poly-fluoroalkyl substances in Santa Clarita groundwater
This study investigates PFAS contamination in Santa Clarita groundwater, focusing on potential sources. The study employs statistical analysis to assess data quality and trends which allowed them to identified domestic waste, fire extinguisher materials, and food packaging as the most likely sources of contamination.
Read More...Governing Glioblastoma: A novel therapy to restore motor control and mitigate glioblastoma proliferation
The authors looked at ways that seizures in patients with glioblastoma could be treated using C. elegans as a model system.
Read More...Predicting the spread speed of red imported fire ants under different temperature conditions in China
The authors looked at non-natural factors that influenced the spread rate of fire ants in multiple cities in China.
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