Heliobacter felis causes gastritis which is accompanied by a range of unpleasant symptoms in small animals such as cats. In order to identify effective antibiotics for treating H. felis infections, the researchers investigate whether a combination of different antibiotics is more effective than the use of individual antibiotics alone. Of the antibiotics they selected, Streptomycin alone was better than any other single antibiotic or in combination. Their results have not yet been validated in live animals, but suggest that Streptomycin alone might be an effective treatment of H. felis-induced gastritis in cats.

In this article the authors looked at the effect of spending time with a therapy dog before and after stressful events. They found that interacting with a therapy before a stressful event showed more significant reduction in signs of stress compared to interacting with a therapy dog after stressful events have already occurred.

Physical therapy, especially for patients with spinal cord injuries, can be a difficult and tedious experience. This can result in negative health outcomes, such as patients dropping out of physical therapy or developing additional health problems. In this study, the authors develop and test a potential solution to these challenges: a mixed reality game called Skyfarer that replaces a standard physical therapy regimen with an immersive experience that can be shared with their friends and family. The findings of this study suggest that mixed reality games such as Skyfarer could be effective alternatives to conventional physical therapy.

Pancreatic cancer is one of the deadliest cancers, with a 10% 5-year survival rate. The authors studied various dosages of TPEN and zinc in combination with Chloroquine and Gemcitabine as treatments to reduce cell proliferation. Results showed that when combined with Chloroquine and Gemcitabine, zinc and TPEN both significantly lowered cell proliferation compared to Gemcitabine, suggesting a synergistic effect that resulted in a more cytotoxic treatment. Further research and clinical trials on this topic are needed to determine whether this could be a viable treatment for pancreatic cancer.

Here, recognizing the important role of bacterial biofilms in many life-threatening chronic infections, the authors investigated the effectiveness of a combination treatment on biofilms composed of up to three different common species within the lungs of cystic fibrosis patients with computational analysis. They found that a triple cocktail therapy targeting three different signaling pathways has significant potential as both a treatment and prophylaxis.

Wound-healing involves a sequence of events, such as inflammation, proliferation, and migration of different cell types like fibroblasts. Zinc Finger CCCH-type with G-Patch Domain Containing Protein (ZGPAT), encodes a protein that has its main role as a transcription repressor by binding to a specific DNA sequence. The aim of the study was to find out whether inhibiting ZGPAT will expedite the wound healing process by accelerating cell migration. This treatment strategy can provide a key to the development of wound healing strategies in medicine and cellular biology.

A primary cause of diabetes is insulin resistance, which is caused by disruption of insulin signal transduction. The objective of this study was to maximize insulin sensitivity by creating a more effective, early intervention-based treatment to avert severe T2D. This treatment combined metformin, “the insulin sensitizer”, and medicinal plants, curcumin, fenugreek, and nettle.

In this study, the authors investigate a potential case of cross antibiotic-resistance. Using swabs from an individual who received long-term treatments of azithromycin, they addressed the question of whether any bacteria in this individual might develop resistance to not only azithromycin, but also other antibiotics with similar structures. This study cleverly addresses the important issue of antibiotic resistance from a new and thoughtful approach.

Sesame (Sesamum indicum) and moringa (Moringa oleifera) have natural antioxidants that could prevent cancer growth. Previously, this group found that sesame and moringa individually suppress eye tumor grown in the Drosophila melanogaster model. In the present study, combinations of sesame and moringa at different concentrations were included in the D. melanogaster diet. The impact on eye tumor development was assessed at different stages of growth.

Ethinyl estradiol and progestin norgestrel are commonly present in contraceptive tablets and it is unknown how they affect the environment. In this study, the authors investigate the role that ethinyl estradiol and progestin norgestrel have on the growth of flowering plants. The percentage germination, embryonic and adventitious tissue proliferation, root length, and shoot length were measured in V. radiata and T. aestivum treated with each compound and results demonstrate that ethinyl estradiol and progestin norgestrel can induce growth in both plants at certain concentrations. These findings have important implications as societal use of chemicals increases and more make their way into the environment.