In this study, the authors identify new potential targets to treat advanced diffuse large B-cell lymphoma after treatment relapse and loss of CD19 expression.

Kadıoğlu and Oğuzalp study the synergistic effects of Metformin and Captopril, two commonly prescribed drugs for type 2 diabetes and hypertension, respectively. Using C. elegans nematodes as a model system, the authors find that the nematodes decreased in average body length when exposed to Metformin or Captopril individually, but grew 11% in body length when both drugs were used together. Because C. elegans body size is regulated in part by the TGF-β signaling pathway, the authors suggest that synergistic effects of these two drugs may be modulating TGF-β activity, a previously uncharacterized phenomenon.

In this study, the authors investigate whether Moringa Oleifera seeds can serve as material to aid in purifying water. M. oleifera seeds have coagulating properties and the authors hypothesized that including it in a water filtration system would reduce particles, specifically bacteria, in water. Their results show that this system removed the largest percent of bacteria. When used in combination with cilantro, it was actually more efficient than the other techniques! These findings have important implications for creating better and more economical water purification systems.

Unsatisfactory hand hygiene leads to the spread of bacterial infections from person to person. To address this problem, the authors developed and tested the PeelTowel, an antibacterial and water-absorbing towel made of a combination of fruit peels and recycled paper waste.

Parkinson's disease is a neurodegenerative disorder that affects over 10 million people worldwide. It is caused by destruction of dopamine-producing neurons, which results in severe motor and movement symptoms. In this study, the authors investigated the anti-Parkinsonian effects of two natural compounds curcumin and nicotinamide using C. elegans as a model organism.

Berberine, a natural product alkaloid, has been shown to exert biological activity via in situ production of singlet oxygen when photo irradiated. Berberine utilizes singlet oxygen in its putative mechanism of action, wherein it forms an activated complex with DNA and photosensitizes triplet oxygen to singlet oxygen to specifically oxidize guanine residues, thereby halting cell replication and leading to cell death. This has potential application in photodynamic therapy, alongside other such compounds which also act as photosensitizers and produce singlet oxygen in situ. The quantification of singlet oxygen in various photosensitizers, including berberine, is essential for determining their photosensitizer efficiencies. We postulated that the singlet oxygen produced by photoirradiation of berberine would be superior in terms of singlet oxygen production to the aforementioned photosensitizers when irradiated with UV light, but inferior under visible light conditions, due to its strong absorbance of UV wavelengths.

Here, the authors chose to investigate the efficacy of zinc oxide nanoparticles (ZnO NPs) and cisplatin or zinc ions in inducing cancer apoptosis. While both treatments were found to reduce the proliferation of lung cancer cells, the authors suggest that further studies to identify the mechanism are necessary.

Overwatering and underwatering grass are widespread issues with environmental and financial consequences. This study developed an accessible method to assess grass water use efficiency (WUE) combining smartphone imaging with open access color unmixing analysis. The method can be applied in automated irrigation systems or apps, providing grass WUE assessment for regular consumer use.

Intelligent vehicles utilize a combination of video-enabled object detection and radar data to traverse safely through surrounding environments. However, since the most momentary missteps in these systems can cause devastating collisions, the margin of error in the software for these systems is small. In this paper, we hypothesized that a novel object detection system that improves detection accuracy and speed of detection during adverse weather conditions would outperform industry alternatives in an average comparison.

Ant invasion causes damage exceeding $5 billion annually in North America. In this study, Ambati and Duvvuri aim to identify natural products with ant-repelling properties using a custom ring apparatus designed to quantify ant-repellence. They report that cinnamon and lemon were the most effective ant repellents of the tested products. These data suggest that compounds found in non-toxic household products, such as cinnamon oil and lemon juice, could be used in low-dose combinations as potent, effective, eco-friendly, and safe ant repellents.